A novel-generation 3D cell culture bioreactor for rapid cell colonization in a 3D manner enabling an in vitro real reconstruction of tissue complexity, in an in vivo-like microenvironment.
VITVO it’s a ready to use, flat and handheld bioreactor, integrating scaffold for the establishment of in vitro 3D cell culture model that can be used for a large number of research applications and pre-clinical investigations. This in vitro 3D cell culture technology offers also a solution for precision medicine approaches.
Time Saving
VITVO is a ready-to-use device for rapid loading, cell colonization, fast monitoring and obtainment of results (readouts after few hours).
Flexibility
Versatility to different R&D strategies and more complex applications (i.e. co-cultures and fluidics). The platform can host different cell types (normal/tumoral) simultaneously.
Transportability
Self-contained technology ensures an easy handling, the transportability and the minimization of contaminations, maintaining gas exchanges.
Sizing
Technical features of VITVO are compatible with millions of cells reducing the over-efficacy bias of the miniaturized 2D cultures. VITVO offers the optimal compromise between the reduction of culture medium volume and a successful creation of a tissue structure.
Reproducibility
The standardized procedures of production and use of VITVO lead to a homogeneous distribution of cells and to high-reproducible readouts.
Accuracy
The tissues created in VITVO closely mimic the in vivo microenvironment, providing a parallelism with in vivo studies.
Handling VITVO…
VITVO Workshop
Our 1-hour workshop will inspire scientists to get their experimental application in a 3D system. You can discuss your unmet needs with us, learn tips and see published experimental data for a 3D deeper experience! …and also ask for a training in our company!
Write to us if you are interested in a workshop on this 3D cell technology! We will be glad to organize it in your institute!
A Concrete Solution for the 3Rs
VITVO thanks to its peculiarities can host human and animal cells to at least reduce and replace small animal studies with both ethical and economic impacts in drug development.
VITVO positioning between the in vitro high throughput screening and the in vivo models will reduce costs of drug screening improving the reliability of pre-clinical testing for safety (i.e. normal hepatocytes) and efficacy (i.e. cancer cell lines or primary tumor cells).
A Valuable Tool for Precision Medicine
VITVO can be loaded with human primary tumor cells dissociated after biopsies or surgery to grow them into their recreated 3D microenvironment and test them with different drugs for predictive purposes.
VITVO Technical Specifications
Material
Device Frame: TPE
3D Matrix: hydrophilically coated PBT
Oxygenation Membranes: PMP
Size
Matrix volume: 4 cm2 (area) x 400 µm (thickness)
Empty volume: 90% of matrix volume
Production
The automated fabrication is performed in the clean room, by the innovative technology without any additives and gluing agents
Biological safety
Inert, biocompatible and xeno-free
DNAse/RNAse free
Sterilization
Electron-beam processing
Storage and warehousing
Two years shelf life
